CBD Drug Interactions Explained

cbd interactions

CBD Drug Interactions Explained

There are a number of individuals who are currently on medications who are considering using CBD to alleviate some side effects of their daily medications. There are also instances where the prescribed medication is not covering certain symptoms of their health issue. For these reasons, some seek to supplement their treatment with CBD. However, before you do so, it is important that you consider whether or not CBD interacts with medications.

Can CBD Oil Interact with Medications?
The short answer is that CBD does interact with medication. How this works is that CBD inhibits the cytochrome P450 enzyme. This enzyme is critical to the body’s work of breaking down drugs. The interaction between CBD oil, edibles or any of its forms is similar to that of grapefruit, which also inhibits the same enzymes. This is the reason behind your doctor’s advice to avoid grapefruit with certain medication. The inhibition of P450 makes consuming CBD while taking medication a risky decision. So, can CBD oil interact with medications? Yes. Cannabidiol or CBD is capable of changing the way your body process medications. While it has gained much attention due to its potential health benefits for people facing insomnia, anxiety, chronic pain, and many other conditions, you may want to think twice about taking other treatment along with CBD.

It is wise to speak with your medical doctor before moving forward with the consumption of CBD while being on other medication.

P450, CBD and Medications
The family of enzymes categorized as P450 is critical to the body’s ability to metabolize a number of cannabinoids. This includes CBD. Particularly, P3A4, a prominent member of the P450 family, handles this duty. When you consume CBD it also affects P3A4. This important enzyme is needed to metabolize approximately 60% of the current clinically prescribed medications. However, if you are consuming CBD while taking one of these clinically prescribed medications, your body will not be able to efficiently break down the medications and this can be a major problem. While that side of the story should not be ignored, there is another side. Some medications inhibit the work of P3A4. This means that if you are to consume CBD while being on these medications, your body will not be able to process the CBD in an efficient appropriate manner.

Therefore, if you notice a delay in your body’s work of breaking down medication, you could possibly have too much medication in your system. this could ultimately result in dangerous side effects that you will not be pleased with. There are also substances that enhance the impact of P450 enzymes. If you find that your body is breaking down the medication you are taking way too fats, it could be evidence that there is a substance present that is inducing the enzymes. It could also mean that you have not taken enough of the medication to effectively tackle your health concern.

Safely Using CBD While on Medications
If you feel convicted about using CBD while you are taking medications, the first thing you should do is talk to your doctor. This cannot be said enough. Your doctor will be able to walk you through an appropriate approach to take CBD so as to avoid CBD interactions or at least minimize the interactions. They will be able to guide you to which CBD product to use, the frequency of its usage and guidance on the dosage to take while on your medications. Please do not stop using your medication in favor of CBD usage without first consulting your doctor.

We have already established that, however, in an effort to avoid the level of interaction from such things as CBD oil, you could try lotions, creams and salves with the guidance of your doctor. Edibles, vaping solutions, and oils usually enter the bloodstream. This is not necessarily the case with topicals.

Avoiding Potential CBD Interactions
One way that you can avoid the negative interactions from using CBD while on medications is to find out if your medication has a grapefruit warning.While the studies are still working to find out the interactions that exist between CBD and certain medications, there is a practice that can help to protect you. Do not take CBD if your medication has a grapefruit warning on it.

Eating grapefruit while taking certain medications can result in a much higher concentration of the medication in the bloodstream. This, of course, can lead to terrible side effects including overdose. Here are some medications that that usually have a grapefruit warning:

  • alprazolam
  • amiodarone
  • atorvastatin
  • carbamazepine
  • cilostazol
  • clarithromycin
  • colchicine
  • dronedarone
  • erythromycin
  • felodipine
  • fentanyl
  • fentanyl transdermal system
  • fexofenadine
  • indinavir
  • loratadine
  • losartan

The Most Important Thing: Speak with Your Doctor About CBD Interactions
Most doctors will suggest that you should stay away from CBD when you are taking medications because of the impact it has on the metabolization of the medications. Beware of medication such as anti-anxiety drugs and blood thinners. Again, if you are highly convinced that you can benefit from CBD while taking your current medications, be sure to speak with your doctor who will be able to give you the requisite guidance. CBD has proven itself to be safe and benign. It is even much safer than many drugs states researchers. While this is true, we must be aware that it does have certain effects on the biochemistry of the body.

The same care that you take when considering what to put in your body should be exhibited when you are taking CBD. The facts surrounding its interactions with medication, reveals to us that we must be careful when mixing CBD with other treatment. This does not belittle the wealth of research that shows that CBD can indeed provide health benefits. Seek out the expertise of physicians who are well informed in the realm of CBD and its effects on health and the body’s ability to break down medication while consuming it.

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