Does CBD Interact or Interfere with Medication?

can cbd oil interact with medications

Does CBD Interact or Interfere with Medication?

Although the therapeutic value of CBD is very well known, taking it alongside other medications is another story. The first thing you should know is that while CBD is considered a natural alternative to many drugs, it has its own set of beneficial and adverse effects. Can CBD oil interact with medications? Yes, but before getting into this topic, it is important to understand how CBD is processed by the human body in the first place.

How Does the Human Body Metabolize CBD?
When you orally take CBD, your body processes it in the same way as most other drugs. Cannabidiol enters your digestive tract and then your stomach lining slowly absorbs it into the hepatic portal system. It is a system of veins that connects the stomach to the liver. It basically works as one of the filters of the body.

Most drugs have relatively low bioavailability, this means only a small amount of them passes through the hepatic portal system into the liver. Once they reach there, they are metabolized and turned into a variety of other substances known as metabolites. When it comes to CBD, the evidence suggests that some of its metabolites may be very beneficial while others may have adverse effects. As a result, it has the potential to boost or reduce the effectiveness of other drugs.

The Role of Cytochrome P450
About 60% of prescribed medications are processed through the liver by what is known as the P450 family of enzymes. When it comes to metabolizing CBD, Cytochrome 450-complex enzymes play an important role. Once the CBD enters the liver, it takes nearly all the enzymes capability. Because of this, it keeps the liver from breaking down any other drugs that are hepatically metabolized, hence affecting how they work.

The Potential Risks and Benefits of CBD Drug Interactions
There are both positive and negative effects of CBD interactions with other drugs. These effects vary depending on the medicine, drug potency, medical condition, and circumstance.

Potential Risks of CBD Drug Interactions
Although more research is required to verify the subject, it is possible that a strong potency of CBD in the bloodstream could trigger toxic levels of some medications. There are some medications that use the P450 metabolic pathway as well and when they are taken with CBD, it may result in increased serum levels which could be fatal.

Positive Effects of CBD Drug Interactions
CBD interactions with the P450 enzyme may also lead to certain benefits. CBD can increase the potency of certain medications in the bloodstream. This could mean that patients would be able to reduce their dose of those specific medications.

Which Drugs Could CBD Interact with?
As mentioned above, about 60% of prescribed medications are metabolized by the P450 enzyme. So, it is not possible to list all the medications and drugs that CBD interacts or interferes with. Some common types of medications CBD could interfere with include:

• antipsychotics
• opioids
• many antidepressants
• some statins
• antiretrovirals
• haloperidol
• antihistamines
• anticonvulsants
• sildenafil
• cyclosporine
• benzodiazepines
• calcium channel blockers
• macrolides
• beta blockers

The Bottom Line
Can CBD oil interact with medications? Yes. But more research is required to fully understand the positive and negative effects of CBD interactions with drugs. If you want to use CBD with other medications, then it is highly recommended that you consult with a qualified medical professional first.

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